Atenolol
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| Clinical data | |
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| Trade names | Tenormin, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a684031 |
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| Routes of administration | oral, Intravenous (IV) |
| Drug class | Selective β1 receptor antagonist |
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| Pharmacokinetic data | |
| Bioavailability | 40–50% |
| Protein binding | 6–16%[1] |
| Metabolism | Minimal[1] |
| Onset of action | IV: <5 minutes[1] Oral: <1 hour[1] |
| Elimination half-life | 6–7 hours[1] |
| Duration of action | >24 hours[1] |
| Excretion | Urine (>85% IV, 50% oral)[1] |
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| ECHA InfoCard | 100.044.941 |
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| Chirality | Racemic mixture |
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Atenolol (brand name: Tenormin) is a beta blocker medication which treats high blood pressure (hypertension), irregular heartbeats (arrhythmia) and angina.[2]
History and culture[change | change source]
Atenolol was patented in 1969 and approved for medical use in 1975.[3] It is on the World Health Organization's List of Essential Medicines.[4] It is available as a generic medication.[5] In 2021, it was the 47th most commonly prescribed medication in the United States, with more than 14 million prescriptions.[6][7][8]
Uses[change | change source]
For people with high blood pressure, taking atenolol (or other beta blockers) helps prevent future heart disease, heart attacks and strokes. It can also be used to prevent chest pain caused by angina. Atenolol is sometimes prescribed to prevent migraines and help with anxiety.[2]
Action[change | change source]
Atenolol works by slowing down the heart rate, making it easier for the heart to pump blood around the body.[2]
Related pages[change | change source]
References[change | change source]
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "DailyMed - TENORMIN- atenolol tablet". DailyMed. 30 June 2021. Archived from the original on 27 January 2022. Retrieved 20 November 2023.
- ↑ 2.0 2.1 2.2 "Atenolol: medicine for high blood pressure and angina". nhs.uk. 2022-04-06. Retrieved 2024-05-29.
- ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495.
- ↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ↑ "Atenolol Monograph for Professionals". Drugs.com. AHFS. Archived from the original on 18 April 2019. Retrieved 23 December 2018.
- ↑ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ↑ "Atenolol - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ↑ Source Wikipedia