Cancer exodus hypothesis

The cancer exodus hypothesis says that groups of cancer cells (CTC clusters) stay together as they travel and spread in the body. Scientists used to think these groups had to break up into single cells to spread, but now they think the groups can stay together.^[1] The hypothesis says that groups of cancer cells (CTC clusters) enter the bloodstream, move through it together, and then leave the bloodstream at new places without breaking apart.^[2] This helps them spread more easily. This idea is an important step in understanding how cancer spreads and the role of CTC clusters in this process.^[2]^[3]

References

↑ Ring, Alexander; Nguyen-Sträuli, Bich Doan; Wicki, Andreas; Aceto, Nicola (February 2023). "Biology, vulnerabilities and clinical applications of circulating tumour cells". Nature Reviews. Cancer. 23 (2): 95–111. doi:10.1038/s41568-022-00536-4. ISSN 1474-1768. PMC 9734934. PMID 36494603.
↑ ^2.0 ^2.1 Allen, Tyler A.; Asad, Dana; Amu, Emmanuel; Hensley, M. Taylor; Cores, Jhon; Vandergriff, Adam; Tang, Junnan; Dinh, Phuong-Uyen; Shen, Deliang; Qiao, Li; Su, Teng (2019-09-09). "Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential". Journal of Cell Science. 132 (17): jcs231563. doi:10.1242/jcs.231563. ISSN 0021-9533.
↑ Allen, Tyler A. (2024-03-31). "The Role of Circulating Tumor Cells as a Liquid Biopsy for Cancer: Advances, Biology, Technical Challenges, and Clinical Relevance". Cancers. 16 (7): 1377. doi:10.3390/cancers16071377. ISSN 2072-6694. PMID 38611055.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[1] Ring, Alexander; Nguyen-Sträuli, Bich Doan; Wicki, Andreas; Aceto, Nicola (February 2023). "Biology, vulnerabilities and clinical applications of circulating tumour cells". Nature Reviews. Cancer. 23 (2): 95–111. doi:10.1038/s41568-022-00536-4. ISSN 1474-1768. PMC 9734934. PMID 36494603.

[:0-2] 2.0 ^2.1 Allen, Tyler A.; Asad, Dana; Amu, Emmanuel; Hensley, M. Taylor; Cores, Jhon; Vandergriff, Adam; Tang, Junnan; Dinh, Phuong-Uyen; Shen, Deliang; Qiao, Li; Su, Teng (2019-09-09). "Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential". Journal of Cell Science. 132 (17): jcs231563. doi:10.1242/jcs.231563. ISSN 0021-9533.

[3] Allen, Tyler A. (2024-03-31). "The Role of Circulating Tumor Cells as a Liquid Biopsy for Cancer: Advances, Biology, Technical Challenges, and Clinical Relevance". Cancers. 16 (7): 1377. doi:10.3390/cancers16071377. ISSN 2072-6694. PMID 38611055.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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