Chief cell
In the human body, there are three main types of chief cells which include the gastric chief cells, which are found in the stomach and help with digestion; the parathyroid chief cells, located in the parathyroid glands and help control calcium levels; and the type 1 chief cells, which are found in the carotid body and help regulate breathing.
Cell types
[change | change source]The gastric chief cell is a type of cell in the stomach that releases substances called pepsinogen[1] and chymosin. Pepsinogen turns into the digestive enzyme pepsin when it meets hydrochloric acid made by other stomach cells.[2] This type of cell also releases gastric lipase enzymes, which help break down fats into free fatty acids and simpler forms of glycerides.[3] There is evidence that the gastric chief cell releases leptin when food is in the stomach. Leptin has been found in the pepsinogen granules of these cells.[4]
Reference
[change | change source]- ↑ Ramsey, VG; Doherty, JM; Chen, CC; Stappenbeck, TS; Konieczny, SF; Mills, JC (Jan 2007). "The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1". Development. 134 (1): 211–22. doi:10.1242/dev.02700. PMID 17164426.
- ↑ MeSH https://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?mode=&term=Chief+Cells,+Gastric&field=entry
- ↑ "Chief cells (Cytokines & Cells Encyclopedia - COPE)".
- ↑ Picó, C; Oliver, P; Sánchez, J; Palou, A (Oct 2003). "Gastric leptin: a putative role in the short-term regulation of food intake". The British Journal of Nutrition. 90 (4): 735–41. doi:10.1079/BJN2003945. PMID 13129441.