Fluoxetine
Fluoxetine hydrochloride, also known by its trade name Prozac, is an antidepressant medication. It is used to treat depression, obsessive-compulsive disorder and panic disorder, bulimia and other disorders.[1] Fluoxetine is one of a group of antidepressants called selective serotonin reuptake inhibitors (SSRIs). There are newer drugs available to treat these conditions. Fluoxetine remains very popular still.
Fluoxetine was invented by Eli Lilly and Company in 1972 and entered medical use in 1986.[2] It is on the World Health Organization's List of Essential Medicines.[3] It is available as a generic medication.[4] In 2022, it was the 22nd most commonly prescribed medication in the United States, with more than 24 million prescriptions.[5][6]. It is the third most prescribed antidepressant.[7]
Fluoxetine taken during pregnancy is said to cause significant increase in congenital heart defects in newborn babies[8][9] but most babies born to women taking prozac have a normal heart.[10] It has been suggested that fluoxetine therapy may be continued during breastfeeding if it was used during pregnancy or if other antidepressants have not been effective.[11] The drug passes into breastmilk and may cause side effects in nursing babies,[10] so it is important to ask the doctor or midwife for advice on taking it during or after pregnancy.
References
[change | change source]- ↑ "About fluoxetine". nhs.uk. 2022-02-15. Retrieved 2025-04-20.
- ↑ Myers, Richard Leroy (2007). The 100 most important chemical compounds: a reference guide. Westport, Conn: Greenwood Press. ISBN 978-0-313-33758-1.
- ↑ Organization, World Health (2023). "The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023)".
{{cite journal}}: Cite journal requires|journal=(help) - ↑ "FLUoxetine Monograph for Professionals". Drugs.com. Retrieved 2025-04-20.
- ↑ "The Top 300 of 2022". clincalc.com. Retrieved 2025-04-20.
- ↑ "Fluoxetine - Drug Usage Statistics, ClinCalc DrugStats Database". clincalc.com. Retrieved 2025-04-20.
- ↑ After sertraline and escitalopram, see: Top 200 Generic Drugs by Units in 2006PDF (19.4 KiB). Drug Topics (March 5, 2007). Retrieved on April 14, 2007.
- ↑ Gao, Shan-Yan; Wu, Qi-Jun; Sun, Ce; Zhang, Tie-Ning; Shen, Zi-Qi; Liu, Cai-Xia; Gong, Ting-Ting; Xu, Xin; Ji, Chao; Huang, Dong-Hui; Chang, Qing (2018-11-12). "Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births". BMC medicine. 16 (1): 205. doi:10.1186/s12916-018-1193-5. ISSN 1741-7015. PMC 6231277. PMID 30415641.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ↑ "https://unisa.alma.exlibrisgroup.com/discovery/delivery/61USOUTHAUS_INST:UNISA/12212569530001831?lang=en&viewerServiceCode=DigitalViewer". unisa.alma.exlibrisgroup.com. Retrieved 2025-04-20.
{{cite web}}: External link in|title= - ↑ 10.0 10.1 "Pregnancy, breastfeeding and fertility while taking fluoxetine". nhs.uk. 2022-02-15. Retrieved 2025-04-20.
- ↑ "Fluoxetine Use During Pregnancy". Drugs.com. Retrieved 2025-04-20.
