Labetalol
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| Clinical data | |
|---|---|
| Pronunciation | /ləˈbɛtəlɔːl/ |
| Trade names | Normodyne, Trandate, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a685034 |
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| Routes of administration | By mouth, intravenous |
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| Pharmacokinetic data | |
| Bioavailability | 25% |
| Protein binding | 50% |
| Metabolism | Liver pass metabolism, |
| Elimination half-life | Tablet: 6–8 hours; IV: 5.5 hours |
| Excretion | Excreted in urine, not removed by hemodialysis |
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| ChEMBL | |
| ECHA InfoCard | 100.048.401 |
| Chemical and physical data | |
| Chirality | Racemic mixture |
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Labetalol (brand name Trandate,[1] Normodyne) is a beta blocker medication used to treat high blood pressure (hypertension), including high blood pressure in pregnancy.[1]
Taking labetalol helps to prevent future heart disease, heart attacks and strokes in people with high blood pressure,[1] because they are at a higher risk. It can also be used to prevent chest pain caused by angina.[1]
Labetalol was patented in 1966 and came into medical use in 1977.[2] It is available as a generic medication.[3] In 2021, it was the 213th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[4][5][6]
Function[change | change source]
Labetalol works by slowing down the heart rate and making it easier for the heart to pump blood around the body.[1]
References[change | change source]
- ↑ 1.0 1.1 1.2 1.3 1.4 "Common questions about labetalol". nhs.uk. 2022-03-08. Retrieved 2024-05-30.
- ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 463. ISBN 9783527607495.
- ↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 147–148. ISBN 9780857113382.
- ↑ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ↑ "Labetalol - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ↑ Source Wikipedia