"She's a Mystery to Me" is a 1989 song by Roy Orbison and is the second single from his 22nd studio album Mystery Girl. It was written by Bono and the Edge from U2. It went to number 5 in Ireland, number 17 in Australia, number 19 in the Netherlands, number 27 in the United Kingdom and number 30 in New Zealand. It did not chart in the United States.