Template:1921 American League standings
| American League | W | L | Pct. | GB |
|---|---|---|---|---|
| New York Yankees | 98 | 55 | .641 | -- |
| Cleveland Indians | 94 | 60 | .610 | 4 |
| St. Louis Browns | 81 | 73 | .526 | 17½ |
| Washington Senators | 80 | 73 | .523 | 18 |
| Boston Red Sox | 75 | 79 | .487 | 23½ |
| Detroit Tigers | 71 | 82 | .464 | 27 |
| Chicago White Sox | 62 | 92 | .403 | 36½ |
| Philadelphia Athletics | 53 | 100 | .346 | 45 |