User:Mr. Ibrahem/Crizanlizumab
Monoclonal antibody | |
---|---|
Type | Whole antibody |
Source | Humanized |
Target | selectin P |
Clinical data | |
Trade names | Adakveo, Ryverna, others |
Synonyms | SEG101, SelG1, crizanlizumab-tmca |
AHFS/Drugs.com | Monograph |
MedlinePlus | a620010 |
License data |
|
Pregnancy category | |
Routes of administration | Intravenous |
Drug class | P-selectin inhibitor[3] |
Legal status | |
Legal status | |
Chemical and physical data | |
Formula | C6458H9948N1712O2050S58 |
Molar mass | 146,232.04 g·mol−1 |
Crizanlizumab, sold under the brand name Adakveo among others, is a medication used to treat sickle cell disease.[4] Specifically it is used to reduce the frequency of vaso-occlusive crisis in people over 15 years old.[4] It is given by injection into vein.[4]
Common side effects include joint pain, nausea, fever, and abdominal pain.[3] Other side effects may include infusion reactions.[4] Use in pregnancy may harm the baby.[4] It is a monoclonal antibody that binds to and blocks P-selectin, decreasing the attaching of cells to the inside of blood vessels.[3]
Crizanlizumab was approved for medical use in the United States in 2019 and Europe in 2020.[4][3] In the United Kingdom 100 mg costs the NHS about £1,000 as of 2021.[5] This amount in the United States is about 2,400 USD.[6]
References
[change | change source]- ↑ 1.0 1.1 "AusPAR: Crizanlizumab". Therapeutic Goods Administration (TGA). 24 August 2021. Archived from the original on 4 September 2021. Retrieved 4 September 2021.
- ↑ 2.0 2.1 "Adakveo". Therapeutic Goods Administration (TGA). 16 April 2021. Archived from the original on 6 September 2021. Retrieved 6 September 2021.
- ↑ 3.0 3.1 3.2 3.3 3.4 "Adakveo". Archived from the original on 14 November 2021. Retrieved 7 January 2022.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 "DailyMed - ADAKVEO- crizanlizumab injection". dailymed.nlm.nih.gov. Archived from the original on 8 May 2021. Retrieved 7 January 2022.
- ↑ "Crizanlizumab". SPS - Specialist Pharmacy Service. 6 December 2016. Archived from the original on 11 January 2022. Retrieved 7 January 2022.
- ↑ "Crizanlizumab Prices and Crizanlizumab Coupons - GoodRx". GoodRx. Retrieved 7 January 2022.