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User:Mr. Ibrahem/Homatropine

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Mr. Ibrahem/Homatropine
Clinical data
Pronunciationhoe mat' roe peen[2]
Trade namesEquipin, Isopto Homatropine
SynonymsHomatropine hydrobromide
AHFS/Drugs.comMonograph
MedlinePlusa601006
Drug classAnticholinergic[1]
Legal status
Legal status
  • Rx only, not FDA approved, only sold in UK
Pharmacokinetic data
Duration of actionUp to 4 days[1]
Identifiers
  • (N-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate
Chemical and physical data
FormulaC16H21NO3
Molar mass275.35 g·mol−1
3D model (JSmol)
  • CN3[C@H]1CC[C@@H]3C[C@@H](C1)OC(=O)C(O)c2ccccc2
  • InChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3/t12-,13+,14+,15? checkY
  • Key:ZTVIKZXZYLEVOL-MCOXGKPRSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Homatropine, sold under the brand name Homatropaire among others, is a medication used to dilate the pupil as part of an eye exam or to help with the pain of anterior uveitis.[3][1] It is used as an eye drop.[3] Effects begin within 10 minutes and may last for up to 4 days.[1]

Common side effects include increased eye pressure, stinging, sensitivity to light, and dry mouth.[1] Other side effects may include delirium or agitation.[1] It is an anticholinergic.[1]

Homatropine was first made in 1883 or 1884.[4][5] It is available as a generic medication.[2] It is on the World Health Organization's List of Essential Medicines as an alternative to atropine.[6] In the United States a 5 ml bottle costs about 40 USD as of 2021.[7] It is made from atropine.[2]

References

[change | change source]
  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Homatropine Monograph for Professionals". Drugs.com. Archived from the original on 29 September 2021. Retrieved 10 December 2021.
  2. ↑ 2.0 2.1 2.2 "Atropine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 10 December 2021.
  3. ↑ 3.0 3.1 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1211. ISBN 978-0857114105.
  4. ↑ Foley, Paul Bernard (2003). Beans, Roots and Leaves: A History of the Chemical Therapy of Parkinsonism. Tectum Verlag DE. p. 167. ISBN 978-3-8288-8496-0. Archived from the original on 2021-12-11. Retrieved 2021-12-10.
  5. ↑ Sneader, Walter (23 June 2005). Drug Discovery: A History. John Wiley & Sons. p. 121. ISBN 978-0-471-89979-2. Archived from the original on 11 December 2021. Retrieved 10 December 2021.
  6. ↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  7. ↑ "Homatropine ophthalmic Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 29 December 2018. Retrieved 10 December 2021.
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