User:Mr. Ibrahem/Mafenide

Mr. Ibrahem/Mafenide
Clinical data
Trade names	Sulfamylon
Synonyms	Mafenide acetate
AHFS/Drugs.com	Monograph
Routes of; administration	Topical
Drug class	Sulfonamide
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 4-(Aminomethyl)benzenesulfonamide;
Chemical and physical data
Formula	C7H10N2O2S
Molar mass	186.23 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(c1ccc(cc1)CN)N;
	InChI InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11) ; Key:TYMRLRRVMHJFTF-UHFFFAOYSA-N ;
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Mafenide, sold under the brand name Sulfamylon among others, is an antibiotic used to treat and prevent infections in people with burns.^[2] Specifically it may be used for 2nd or 3rd degree burns.^[1] It is applied to the skin as a cream or solution.^[2]

Common side effects include pain at the site it was applied.^[2] Other side effects may include allergic reactions and acidosis.^[2] It should not be used in people with kidney problems.^[3] It is a sulfonamide and is able to get through the eschar.^[1]^[4]

Mafenide was discovered in the 1930s and came into medical use in the 1960.^[3] It is available as a generic medication. In the United States 5 packs cost about 45 USD as of 2021.^[5] It is also available in Japan.^[6]

References

↑ ^1.0 ^1.1 ^1.2 Rosenthal, Laura; Burchum, Jacqueline (17 February 2017). Lehne's Pharmacotherapeutics for Advanced Practice Providers - E-Book. Elsevier Health Sciences. p. 822. ISBN 978-0-323-44779-9. Archived from the original on 14 November 2021. Retrieved 14 November 2021.
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 "Mafenide Monograph for Professionals". Drugs.com. Archived from the original on 27 January 2021. Retrieved 14 November 2021.
↑ ^3.0 ^3.1 Wilson, William C.; Grande, Christopher M.; Hoyt, David B. (5 February 2007). Trauma: Resuscitation, Perioperative Management, and Critical Care. CRC Press. p. 944. ISBN 978-1-4200-1526-3. Archived from the original on 14 November 2021. Retrieved 14 November 2021.
↑ Cancio, Leopoldo C. (1 February 2021). "Topical Antimicrobial Agents for Burn Wound Care: History and Current Status". Surgical Infections. 22 (1): 3–11. doi:10.1089/sur.2020.368.
↑ "Mafenide Prices and Mafenide Coupons - GoodRx". GoodRx. Retrieved 14 November 2021.
↑ "Sulfonamides - Infectious Diseases". Merck Manuals Professional Edition. Archived from the original on 30 October 2021. Retrieved 14 November 2021.

[Ros2017-1] 1.0 ^1.1 ^1.2 Rosenthal, Laura; Burchum, Jacqueline (17 February 2017). Lehne's Pharmacotherapeutics for Advanced Practice Providers - E-Book. Elsevier Health Sciences. p. 822. ISBN 978-0-323-44779-9. Archived from the original on 14 November 2021. Retrieved 14 November 2021.

[AHFS2021-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 "Mafenide Monograph for Professionals". Drugs.com. Archived from the original on 27 January 2021. Retrieved 14 November 2021.

[Wil2007-3] 3.0 ^3.1 Wilson, William C.; Grande, Christopher M.; Hoyt, David B. (5 February 2007). Trauma: Resuscitation, Perioperative Management, and Critical Care. CRC Press. p. 944. ISBN 978-1-4200-1526-3. Archived from the original on 14 November 2021. Retrieved 14 November 2021.

[4] Cancio, Leopoldo C. (1 February 2021). "Topical Antimicrobial Agents for Burn Wound Care: History and Current Status". Surgical Infections. 22 (1): 3–11. doi:10.1089/sur.2020.368.

[5] "Mafenide Prices and Mafenide Coupons - GoodRx". GoodRx. Retrieved 14 November 2021.

[6] "Sulfonamides - Infectious Diseases". Merck Manuals Professional Edition. Archived from the original on 30 October 2021. Retrieved 14 November 2021.

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