User:Mr. Ibrahem/Mipomersen
Clinical data | |
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Trade names | Kynamro |
Synonyms | ISIS 301012 |
AHFS/Drugs.com | Monograph |
Pregnancy category | |
Routes of administration | Subcutaneous injection |
Drug class | Antisense oligonucleotide[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Protein binding | ≥90% |
Metabolism | Nucleases |
Elimination half-life | 1–2 months |
Excretion | <4% in urine in 24 hours |
Identifiers | |
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Chemical and physical data | |
Formula | C230H305N67Na19O122P19S19 |
Molar mass | 7,594.76 g·mol−1 |
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Mipomersen, sold under the brand name Kynamro, is a medication used to treat homozygous familial hypercholesterolemia.[2] Effects on overall risk of heart disease or death is unclear.[2] Benefits in other types of high cholesterol is unknown.[2] It is given by injection under the skin.[2]
Common side effects include tiredness, nausea, headache, liver problems, fever, high blood pressure, and abdominal pain.[2] Other side effects may include pain at the site of injection and angioedema.[2] It is a short fragment of DNA, known as an antisense oligonucleotide, that blocks the production of apolipoprotein B.[1]
Mipomersen was approved for medical use in the United States in 2013.[2] In Europe it was denied approval in 2013 due to concerns of greater side effects than benefits.[1] In the United States it costs about 407,000 USD per year.[3]
References
[change | change source]- ↑ 1.0 1.1 1.2 "Kynamro". Archived from the original on 8 March 2021. Retrieved 18 November 2021.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 "Mipomersen Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 18 November 2021.
- ↑ "Kynamro Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 18 November 2021.